![]() The first symptoms are often mistakenly attributed to aging or stress. First symptoms Stages of atrophy in Alzheimer's As the disease progresses so does the degree of memory impairment. The disease is known to target the hippocampus which is associated with memory, and this is responsible for the first symptoms of memory impairment. The three stages are described as early or mild, middle or moderate, and late or severe. ![]() The course of Alzheimer's is generally described in three stages, with a progressive pattern of cognitive and functional impairment. It is ranked as the seventh leading cause of death in the United States. Alzheimer's financial burden on society is large, with an estimated global annual cost of US$1 trillion. The disease is named after German psychiatrist and pathologist Alois Alzheimer, who first described it in 1906. It affects about 6% of people 65 years and older, and women more often than men. It most often begins in people over 65 years of age, although up to 10% of cases are early-onset impacting those in their 30s to mid-60s. Īs of 2020, there were approximately 50 million people worldwide with Alzheimer's disease. Behavioral problems or psychosis due to dementia are often treated with antipsychotics, but this is not usually recommended, as there is little benefit and an increased risk of early death. Exercise programs may be beneficial with respect to activities of daily living and can potentially improve outcomes. The pressures can include social, psychological, physical, and economic elements. ![]() Affected people become increasingly reliant on others for assistance, often placing a burden on caregivers. No treatments can stop or reverse its progression, though some may temporarily improve symptoms. ![]() Good nutrition, physical activity, and engaging socially are known to be of benefit generally in aging, and may help in reducing the risk of cognitive decline and Alzheimer's. Examination of brain tissue is needed for a definite diagnosis, but this can only take place after death. Initial symptoms are often mistaken for normal brain aging. A probable diagnosis is based on the history of the illness and cognitive testing, with medical imaging and blood tests to rule out other possible causes. The disease process is largely associated with amyloid plaques, neurofibrillary tangles, and loss of neuronal connections in the brain. Other risk factors include a history of head injury, clinical depression, and high blood pressure. The strongest genetic risk factor is from an allele of APOE. There are many environmental and genetic risk factors associated with its development. The cause of Alzheimer's disease is poorly understood. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. Gradually, bodily functions are lost, ultimately leading to death. As a person's condition declines, they often withdraw from family and society. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues. The most common early symptom is difficulty in remembering recent events. Life expectancy 3–9 years Īlzheimer's disease ( AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, and is the cause of 60–70% of cases of dementia. Normal brain aging, Lewy body dementia, Trisomy 21 Īcetylcholinesterase inhibitors, NMDA receptor antagonists (small benefit) Genetics, head injuries, depression, hypertension īased on symptoms and cognitive testing after ruling out other possible causes Memory loss, problems with language, disorientation, mood swings ĭehydration and pneumonia in the terminal stage / ˈ æ l t s h aɪ m ər z/, US also / ˈ ɑː l t s-/.Variants of the name include Blighe, Bligh, Blight, Blyth, Blith, Blithe and Blygh. Blythe is a feminine given name from an Old English surname with the same spelling meaning "cheerful", "joyous", "pleasant", dating further back from the Proto-Germanic word blithiz, meaning "gentle", "kind".
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